Sydney: A gene which the researchers have now identified with the effect that it can cause defects in insulin secretion in the patients with the Type- 2 diabetes and those others with the Down syndrome.
Notably, it is popular that the diabetes are of two types and people with type- 2 diabetes generally face its association with the obesity and insulin resistance due to pancreatic beta- cell dysfunction. Also, people with the Down syndrome, are also generally experiencing the lower insulin secretion, mitochondrial dysfunction and increased oxidative stress in the insulin- producing beta cells.
To reach to the results, the researchers conducted an experiments with the mice, and found that the over expression of the gene RCAN1 can cause these problems. Moreover, the researchers also seemed suggesting that the said gene may also be playing a lead role in development of Type- 2 diabetes.
The findings in the study are published in detailed in the journal PLOS Genetics. And the team of researchers is led by the Professor- Damien Keating, from the Flinders University in Australia. The researchers’ team used four mouse models, among them 2 were with high blood sugar and remaining two were without high blood sugar.